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RETINOBLASTOMA LIKE PROTEIN P130
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DeCS
Descriptor
English
:
Retinoblastoma-Like Protein p130
Descriptor
Spanish
:
Proteína p130 Similar a la del Retinoblastoma
Descriptor
Portuguese
:
Proteína p130 Retinoblastoma-Like
Synonyms
English
:
RBL2 Protein
Retinoblastoma Like Protein 2
Retinoblastoma Like Protein p130
Retinoblastoma-Like Protein 2
p130, Retinoblastoma-Like Protein
Tree Number:
D12.776.624.776.735
D12.776.660.794
D12.776.744.755
Definition
English
:
A negative regulator of the
CELL CYCLE
that undergoes
PHOSPHORYLATION
by
CYCLIN-DEPENDENT KINASES
. RBL2 contains a conserved pocket region that binds
E2F4 TRANSCRIPTION FACTOR
and
E2F5 TRANSCRIPTION FACTOR
. RBL2 also interacts with viral ONCOPROTEINS such as
POLYOMAVIRUS
TUMOR
ANTIGENS
;
ADENOVIRUS E1A PROTEINS
; and
PAPILLOMAVIRUS E7 PROTEINS.
History Note
English
:
2006(1994)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
51163
Unique Identifier:
D050717
Occurrence in VHL
:
Similar:
DeCS